abstract：:Experiments were performed to determine whether diurnal variations in apoptosis in the mouse small intestine after irradiation with 2.5 Gy gamma rays depended on the time of day that the mice were irradiated, the time of day that the mice were sacrificed or the interval between irradiation and sacrifice. Experiments w...

journal_title：Radiation research

authors： Ruifrok AC,Weil MM,Thames HD,Mason KA

更新日期：1998-04-01 00:00:00

abstract：:Exposure of the major salivary glands to ionizing radiation often results in severe alterations in structure and function. The mechanism of these effects is still unknown, and no adequate prevention or treatment is yet available. The purpose of this study was to examine a mechanism based on the assumption that redox-a...

journal_title：Radiation research

authors： Nagler R,Marmary Y,Golan E,Chevion M

更新日期：1998-03-01 00:00:00

abstract：:We examined the effects of X irradiation on activation of the promoter of the human HSP70B gene, which is activated only after heat shock. The HSP70B promoter was ligated to the bacterial beta-galactosidase (beta-gal) gene, and the reporter plasmid was transfected into NCI-H1299 carcinoma cells. The expression of the ...

journal_title：Radiation research

authors： Suzuki K,Kodama S,Watanabe M

更新日期：1998-02-01 00:00:00

abstract：:Single crystals of the co-crystalline complex of 1-methyluracil and 9-ethyladenine were X-irradiated and studied using EPR, ENDOR and FSE spectroscopic techniques at 10 K. All together seven radicals were identified, and experimental evidence for at least one more species, as well as for a very low population of radic...

journal_title：Radiation research

authors： Sagstuen E,Hole EO,Nelson WH,Close DM

更新日期：1998-02-01 00:00:00

abstract：:The appearance of prostaglandins and thromboxane in mouse serum after X irradiation was observed by simultaneous quantitative analysis using gas chromatography/mass spectrometry/selected ion monitoring with stable isotope dilution methods. Mice of two strains (C57BL/CN Jcl and BALB/c) showed similar responses to X irr...

journal_title：Radiation research

authors： Yamaoka K,Obata T,Iriyama K,Iwasaki T,Hoshi Y

更新日期：1998-01-01 00:00:00

abstract：:The effects of 60Co gamma rays on calcitonin gene-related peptide (CGRP)-immunoreactive nerve fibers and neuropeptide Y (NPY)-immunoreactive nerve fibers were examined in mesenteric blood vessels of rats. Using a free-floating immunostaining streptavidin-biotin peroxidase complex method combined with a nickel-enhancem...

journal_title：Radiation research

authors： Zhang CG,Cai WQ,Li Y,Huang WQ,Su HC

更新日期：1998-01-01 00:00:00

abstract：:In an attempt to elucidate mechanisms underlying the variation in radiosensitivity during the cell cycle, mutations in the HPRT gene were selected with 6-thioguanine, quantified and characterized in synchronous human bladder carcinoma cells (EJ30-15) that were irradiated in G1 or S phase with 3 or 6 Gy. Synchronous ce...

journal_title：Radiation research

authors： Leonhardt EA,Trinh M,Forrester HB,Johnson RT,Dewey WC

更新日期：1997-12-01 00:00:00

abstract：:Induction of interphase death was examined in Chinese hamster ovary cells exposed to accelerated heavy ions (carbon, neon, argon and iron) of various linear energy transfers (LETs) (10-2000 keV/microm). The fraction of cells that underwent interphase death was determined by observing individual cells with time-lapse p...

journal_title：Radiation research

authors： Sasaki H,Yatagai F,Kanai T,Furusawa Y,Hanaoka F,Zhu WG,Mehnati P

更新日期：1997-11-01 00:00:00

abstract：:Human T lymphocytes can be used to determine the frequency and molecular spectrum of somatic cell gene mutations induced by ionizing radiations both in vivo and in vitro. In vitro exposure of these G0 cells to low-LET 137Cs gamma rays results in the induction of HPRT mutations and a predominant molecular spectrum of D...

journal_title：Radiation research

authors： Albertini RJ,Clark LS,Nicklas JA,O'Neill JP,Hui TE,Jostes R

更新日期：1997-11-01 00:00:00

abstract：:The radiation environment in low-Earth orbit is a complex mixture of galactic cosmic radiation, particles of trapped belts and secondary particles generated in both the spacecraft and Earth's atmosphere. Infrequently, solar energetic particles are injected into the Earth's magnetosphere and can penetrate into low-Eart...

journal_title：Radiation research

authors： Badhwar GD

更新日期：1997-11-01 00:00:00

abstract：:Radiation sensitivity was measured by the micronucleus assay in T lymphocytes of the spleen and in fibroblasts derived from three inbred strains of mice, BALB/c, A/J and C3H/He. A linear correlation between the surviving fraction and the micronucleus frequency was obtained. There were clear differences in the radiosen...

journal_title：Radiation research

authors： Kinashi Y,Ono K,Abe M

更新日期：1997-10-01 00:00:00

abstract：:Our data (Reddy et al., Radiat. Res. 141, 252-258, 1995) on the kinetics of the repair of potentially lethal damage in log-phase Chinese hamster V79 cells are used to test some predictions which arise from the different assumptions of the repair-misrepair (RMR) (C. A. Tobias, Radiat. Res. 104, S77-S95, 1985), lethal-p...

journal_title：Radiation research

authors： Lange CS,Mayer PJ,Reddy NM

更新日期：1997-09-01 00:00:00

abstract：:Ionizing radiations induce mutations which can be detected both in coding sequences (Hprt locus) by measuring the frequency of 6-thioguanine-resistant cells and in minisatellite sequences by DNA fingerprint analysis. We analyzed the effects of irradiation with low-energy protons (31 keV/pm) and, for comparison, with u...

journal_title：Radiation research

authors： Ogheri S,Bruna V,Cera F,Favaretto S,Cherubini R,Celotti L

更新日期：1997-09-01 00:00:00

abstract：:To evaluate the usefulness of the transgenic Muta mouse for investigating radiation-induced mutations in vivo, we have examined the effects of whole-body X irradiation and compared them to the effects of ultraviolet light. The spontaneous mutation frequencies in young adults were about 7 x 10(-5) in the spleen, liver ...

journal_title：Radiation research

authors： Ono T,Ikehata H,Hosoi Y,Shung BS,Kurishita A,Wang X,Yamamoto K,Suzuki T,Sofuni T

更新日期：1997-08-01 00:00:00

abstract：:An analysis was conducted of 27,982 deaths among 106,020 persons employed at four Federal nuclear plants in Oak Ridge, Tennessee, between 1943 and 1985. The main objectives were to extend the evaluation of the health effects of employment in the nuclear industry in Oak Ridge to include most workers who were omitted fr...

journal_title：Radiation research

authors： Frome EL,Cragle DL,Watkins JP,Wing S,Shy CM,Tankersley WG,West CM

更新日期：1997-07-01 00:00:00

abstract：:This laboratory previously demonstrated that hyperbaric oxygen and hyperbaric carbogen improved oxygenation in the R3230Ac tumor, but normobaric 100% O2 and carbogen did not. The current study assessed tumor growth after exposure to radiation plus either hyperbaric oxygen, carbogen or carbogen/nicotinamide and the rel...

journal_title：Radiation research

authors： Brizel DM,Hage WD,Dodge RK,Munley MT,Piantadosi CA,Dewhirst MW

更新日期：1997-06-01 00:00:00

abstract：:Nearly 2% of the male population of Estonia aged 20-39 years were sent to Chernobyl to assist in the cleanup activities after the reactor accident. A cohort of 4,833 cleanup workers was assembled based on multiple and independent sources of information. Information obtained from 3,704 responses to a detailed questionn...

journal_title：Radiation research

authors： Tekkel M,Rahu M,Veidebaum T,Hakulinen T,Auvinen A,Rytömaa T,Inskip PD,Boice JD Jr

更新日期：1997-05-01 00:00:00

abstract：:The efficacy of photodynamic therapy is dependent upon the optical dose rate or upon the fractionation schedule on the light. These effects are thought to be limited by the time required for oxygen diffusion from the capillaries, since this therapy can consume oxygen faster than it can be supplied to tissues distant f...

journal_title：Radiation research

authors： Pogue BW,Hasan T

更新日期：1997-05-01 00:00:00

abstract：:The mutagenic activity of green (532 nm) and infrared (1064 nm) ultra-short laser light pulses was tested in cultured Syrian hamster fibroblasts by a hypoxanthine phosphoribosyl-transferase (HPRT) mutagenesis assay. In 18 irradiation trials, cells were exposed to eight consecutive 100-ps pulses of either 532 nm or 106...

journal_title：Radiation research

authors： Leavitt J,Fatone M,Hestdalen C,Obringer JW,Tillinghast HS Jr

更新日期：1997-04-01 00:00:00

abstract：:The intrinsic radiosensitivity of tumor cells is most frequently reported for asynchronous populations, although cell cycle variation in radiosensitivity is known to be significant. Linear-quadratic analyses of survival data for asynchronous human tumor cells show wide variations in the alpha coefficient with smaller ...

journal_title：Radiation research

authors： Biade S,Stobbe CC,Chapman JD

更新日期：1997-04-01 00:00:00

abstract：:The stable free radical 4-oxo-2,2,6,6-tetramethylpiperidinooxy (2,2,6,6-tetramethylpiperidone-N-oxyl, TEMPONE) in nitrous oxide-saturated aqueous formate solution has been shown to be a quantitative dosimeter for in situ radiolysis electron spin resonance (ESR) studies. The bleach of the TEMPONE ESR signal is proporti...

journal_title：Radiation research

authors： Madden KP

更新日期：1997-03-01 00:00:00

abstract：:The effects of reoxygenation on repair of potentially lethal radiation damage were investigated using MG-63 human osteosarcoma cells in vitro. When exponentially growing MG-63 cells were cultured under hypoxic conditions for 24 h, cells stopped growing and remained at a low density. The hypoxic cells were then reoxyge...

journal_title：Radiation research

authors： Iizuka M,Ando K,Aruga T,Furusawa Y,Itsukaichi H,Fukutsu K,Nagasawa H,Moriya H

更新日期：1997-02-01 00:00:00

abstract：:We describe a rapid assay to predict intrinsic radiosensitivity of normal tissues based on the radiation-induced cytotoxic response of a number of types of white blood cells. Twenty-four hours after irradiation, leukocytes were prepared for analysis by flow cytometry. Radiation-induced cytotoxicity was characterized b...

journal_title：Radiation research

authors： Crompton NE,Ozsahin M

更新日期：1997-01-01 00:00:00

abstract：:Hypoadrenocorticism, known as Addison's disease in humans, was diagnosed in six beagles after inhalation of at least 1.7 kBq/g lung of 238PuO2. Histological examination of adrenal gland specimens obtained at necropsy revealed marked adrenal cortical atrophy in all cases. Autoradiographs showed only slight alpha-partic...

journal_title：Radiation research

authors： Weller RE,Buschbom RL,Dagle GE,Park JF,Ragan HA,Watson CR

更新日期：1996-12-01 00:00:00

abstract：:The growth of certain UV-radiation-induced tumors is suppressed by T lymphocytes, but it has been proposed that non-T lymphocytes stimulate the growth of several of these tumors. In this study, the indirect effects of X irradiation on the growth of one such tumor in T-cell-deficient nude mice was tested. Even when the...

journal_title：Radiation research

authors： Seung LP,Weichselbaum RR,Toledano A,Schreiber K,Schreiber H

更新日期：1996-12-01 00:00:00

abstract：:The toxicity of 137Cs in the beagle dog was investigated at the Inhalation Toxicology Research Institute (ITRI) and Argonne National Laboratory (ANL) as part of programs to evaluate the biological effects of both radionuclides in atomic bomb fallout and internally deposited fission-product radionuclides. In the ITRI s...

journal_title：Radiation research

authors： Nikula KJ,Muggenburg BA,Griffith WC,Carlton WW,Fritz TE,Boecker BB

更新日期：1996-11-01 00:00:00

abstract：:Chinese hamster V79 cells show a complex X-ray survival response which is characterized by hypersensitivity followed by increased resistance as the dose increases to 1 Gy. This hypersensitivity can be eliminated by pretreating cells with X rays or hydrogen peroxide. Accordingly, the protective effect that results from...

journal_title：Radiation research

authors： Marples B,Skov KA

更新日期：1996-10-01 00:00:00

abstract：:A histopathological study was carried out on the spinal cord of rats after boron neutron capture (BNC) irradiation. Rats were irradiated with thermal neutrons alone or in combination with borocaptate sodium (BSH) or p-boronophenylalanine (BPA). Spinal cords were examined 1 year after irradiation, or at earlier times i...

journal_title：Radiation research

authors： Morris GM,Coderre JA,Bywaters A,Whitehouse E,Hopewell JW

更新日期：1996-09-01 00:00:00

abstract：:Water:n-octanol partition coefficients (KD) were determined for a series of radioprotective thiols to ascertain whether these could be used to estimate reliably their rates of uptake into mammalian cells by passive diffusion. Values of KD determined for thiols in 0.1 M potassium phosphate, pH 7.4, at 22 degrees C were...

journal_title：Radiation research

authors： Newton GL,Aguilera JA,Kim T,Ward JF,Fahey RC

更新日期：1996-08-01 00:00:00

abstract：:We showed previously that autosomal recessive determinants control the development of pulmonary fibrosis in mice during the early and late phases after irradiation. The extent of fibrosis was inversely correlated with the intrinsic lung activity of both plasminogen activator (PLA) and angiotensin-converting enzyme (AC...

journal_title：Radiation research

authors： Franko AJ,Sharplin J,Ward WF,Taylor JM

更新日期：1996-07-01 00:00:00

abstract：:This continues the series of periodic general reports on cancer mortality in the cohort of A-bomb survivors followed by the Radiation Effects Research Foundation. The follow-up is extended by the 5 years 1986-1990, and analysis includes an additional 10,500 survivors with recently estimated radiation doses. Together t...

journal_title：Radiation research

authors： Pierce DA,Shimizu Y,Preston DL,Vaeth M,Mabuchi K

更新日期：1996-07-01 00:00:00

abstract：:Pregnant Wistar-MS rats received a whole-body irradiation of 0-2.6 Gy gamma rays at day 20 of pregnancy. The mother rats were implanted with a diethylstilbestrol (DES) pellet 30 days after weaning, and the female pups delivered by the irradiated mother were treated with DES after maturation. Lactating rats were irradi...

journal_title：Radiation research

authors： Inano H,Suzuki K,Onoda M,Yamanouchi H

更新日期：1996-06-01 00:00:00

abstract：:Single-strand breaks (SSBs) and double-strand breaks (DSBs) induced in DNA under phosphorus K-shell resonant absorption have been studied using supercoiled plasmids. The kinetics of the production of SSBs and DSBs exhibits a linear and a quadratic dependence, respectively, on photon fluence. Cross sections and quantum...

journal_title：Radiation research

authors： Le Sech C,Frohlich H,Saint-Marc C,Charlier M

更新日期：1996-05-01 00:00:00

abstract：:We measured the production of reactive hydroxyl radical (OH.) by Fe2+ itself or complexed with nucleotide triphosphates or tripolyphosphate (TPP). Coumarin-3-carboxylic acid (3-CCA) reacts with the OH. produced by Fe2+, Fe3+ or Cu2+ plus ascorbate and with various iron complexes. We measured in real time the increased...

journal_title：Radiation research

authors： Biaglow JE,Held KD,Manevich Y,Tuttle S,Kachur A,Uckun F

更新日期：1996-05-01 00:00:00

abstract：:Using five transplantable murine tumors (SCC-VII, B16F1, KHT-C, KHT-LP1, RIF-1), measurements of tumor hypoxia have been made with two techniques which have the potential to be used for assessing oxygenation in human tumors (the Eppendorf pO2 Histograph and binding of [3H]misonidazole) and have been compared with an e...

journal_title：Radiation research

authors： Kavanagh MC,Sun A,Hu Q,Hill RP

更新日期：1996-04-01 00:00:00

abstract：:The current status of particle radiotherapy from a historical perspective is presented. This is done with a personal view and contains personal references and memories during the development of particle radiotherapy. The particles covered are fast neutrons, neutron capture therapy, protons, helium ions, pions and heav...

journal_title：Radiation research

authors： Raju MR

更新日期：1996-04-01 00:00:00

abstract：:We studied heat-induced apoptosis and loss of clonogenicity in Rat-1 fibroblasts, thermotolerant Rat-1 (TT Rat-1), Rat-1 transfected with the human hsp-70 gene (M21) and Rat-1 transfected with the human c-myc proto-oncogene (Rat-1:myc). Relative to Rat-1, TT Rat-1 and M21 cells are heat-resistant, but Rat-1:myc cells ...

journal_title：Radiation research

authors： Li WX,Chen CH,Ling CC,Li GC

更新日期：1996-03-01 00:00:00

abstract：:The basic 30-nm chromatin fiber in the mammalian cell consists of an unknown (possibly helical) arrangement of nucleosomes, with about 1.2 kb of DNA per 10-nm length of fiber. Track-structure considerations suggest that interactions of single delta rays or high-LET particles with the chromatin fiber might result in th...

journal_title：Radiation research

authors： Rydberg B

更新日期：1996-02-01 00:00:00

abstract：:Several authors have reported that ionizing radiation can give rise to novel aberrations several mitotic divisions after the exposure. At our institute this phenomenon has been observed in mouse preimplantation embryos. This cell system is uniquely well suited for such investigations because the first three cell divis...

journal_title：Radiation research

authors： Wojcik A,Bonk K,Müller WU,Obe G,Streffer C

更新日期：1996-02-01 00:00:00

abstract：:The repair of X-ray-induced DNA damage related to the proliferating cell nuclear antigen (PCNA) was characterized in human diploid fibroblasts by an indirect immunofluorescence method. PCNA staining induced by X rays was lost after DNase I treatment but not after RNase treatment. The staining was not induced when ATP ...

journal_title：Radiation research

authors： Miura M,Sasaki T,Takasaki Y

更新日期：1996-01-01 00:00:00